P-66: Adequate Exposure to Tacrolimus with Sublingual Administration
نویسندگان
چکیده
منابع مشابه
Clinical pharmacokinetics of oral versus sublingual administration of tacrolimus in adult liver transplant recipients.
OBJECTIVES Oral tacrolimus administration is the common route of drug delivery. Recent studies suggest sublingual administration of tacrolimus as an alternative route may produce comparable drug trough levels with similar or even lower doses than the oral route, especially in lung transplant recipients; however, most of this research does not encompass intraindividual variations compared betwee...
متن کاملUse of sublingual tacrolimus in lung transplant recipients.
BACKGROUND In lung transplant recipients (LTRs), tacrolimus is often utilized as a core component of immunosuppressive regimens. Although tacrolimus can be delivered orally or intravenously, oral tacrolimus is associated with fewer adverse effects. Various reports have suggested that sublingual tacrolimus may be used as an alternative to oral tacrolimus; however, information regarding convertin...
متن کاملDebut of Gastroesophageal Reflux Concomitant with Administration of Sublingual Immunotherapy
Gastroesophageal reflux disease (GORD) is an often debilitating condition characterised by retrograde flow of content from stomach into the oesophagus, where the low pH of the stomach acid irritates the mucosa of the oesophagus. The most dominant symptoms in GORD are pyrosis, regurgitation, and dysphagia. Sublingual immunotherapy (SLIT) was first described in 1986. Following this description, t...
متن کاملTinnitus after administration of sublingual immunotherapy
BACKGROUND/OBJECTIVES Sublingual immunotherapy was first described in 1986. Since then, its use has been increased as an alternative to subcutaneously administered immunotherapy in the treatment of allergic rhinitis. The most common side effects are of oropharyngeal and gastrointestinal in nature, for example, itching, swelling, irritation, ulceration of the oropharynx and nausea, abdominal pai...
متن کاملSublingual administration of detomidine to calves prior to disbudding: a comparison with the intravenous route
OBJECTIVE To study the effects of oromucosal detomidine gel administered sublingually to calves prior to disbudding, and to compare its efficacy with intravenously (IV) administered detomidine. STUDY DESIGN Randomised, prospective clinical study. ANIMALS Twenty dairy calves aged 12.4 ± 4.4days (mean ± SD), weight 50.5 ± 9.0 kg. METHODS Detomidine at 80 μg kg(-1) was administered to ten ca...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2021
ISSN: 0041-1337
DOI: 10.1097/01.tp.0000758068.16750.e4